SAR441255
Product Specifications
UNSPSC Description
SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors. SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].
Target Antigen
GCGR; GLP Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sar441255.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H](CCC(N[C@H](C(O)=O)CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(NCC(N1[C@H](C(N2[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N3[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCC5)=O)CCC4)=O)CCC3)=O)CCCCN)=O)C)=O)CO)=O)CCC2)=O)CCC1)=O)=O)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CCC(O)=O)=O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC9=CC=CC=C9)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CC%10=CNC=N%10)NC(C(C)(C)NC([C@@H](N)CC%11=CNC=N%11)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CCCCCCCCCCCCCCC)=O
Molecular Weight
4866.56
References & Citations
[1]Martin Bossart, et al. Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. Cell Metab. 2022 Jan 4;34(1):59-74.e10.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10031/SAR441255-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10031/
Clinical Information
Phase 1
Curated Selection
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