SB 235375
Product Specifications
UNSPSC Description
SB 235375 is a potent and selective antagonist of the human neurokinin-3 (hNK-3) receptor designed by optimizing the structure of 2-phenyl-4-quinolinecarboxylic acid amide. SB 235375 displays high affinity for the hNK-3 receptor, with significantly higher binding affinities than hNK-2 and hNK-1 receptors. In vitro studies demonstrated its ability to block NK-3 receptor-mediated contraction and calcium mobilization, while in vivo, SB 223412 demonstrated oral and intravenous activity against NK-3 receptor-driven responses in animal models[1].
Target Antigen
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-235375.html
Smiles
O=C(N[C@H](C1=CC=CC=C1)CC)C2=C(C(C3=CC=CC=C3)=NC4=CC=CC=C24)OCC(O)=O
Molecular Weight
440.49
References & Citations
[1]Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem. 1999 Mar 25;42(6):1053-65.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117380/SB-235375-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117380/
Clinical Information
No Development Reported
CAS Number
224961-34-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
M14209-1 100 µg
Anti-Cytokeratin, Acidic (Type I or LMW) (Epithelial Marker) Monoclonal Antibody
Ask
View Details 
MBS2088578-02 5x 96 Tests + MBS2089471 (Support Pack 1,5x 96 Tests)
Human Caspase 14 (CASP14) ELISA Kit DIY Materials
Ask
View Details 
MBS2088578-04 10x 96 Tests + MBS2089471 (Support Pack 1, 10x 96 Tests)
Human Caspase 14 (CASP14) ELISA Kit DIY Materials
Ask
View Details