Farnesyl thiosalicylic acid amide
Product Specifications
UNSPSC Description
Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/farnesyl-thiosalicylic-acid-amide.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC1=C(C=CC=C1)C(N)=O
Molecular Weight
357.55
References & Citations
[1]Goldberg L, et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. J Med Chem. 2009 Jan 8;52(1):197-205.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112666/Farnesyl-thiosalicylic-acid-amide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112666/
Clinical Information
No Development Reported
CAS Number
1092521-74-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
T-003-55 10 μCi
Agouti-Related Peptide (AgRP) (71-132), Form C amide (Human) - I-125 Labeled
Ask
View Details 
MBS289250-04 10x 96 Well
Human MHC class I polypeptide-related sequence A ELISA Kit
Ask
View Details