P7C3-A20

P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment[1][2][3].

Product Specifications

CAS Number

[1235481-90-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/P7C3-A20.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC(CNC1=CC(OC)=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

Molecular Formula

C22H19Br2FN2O

Molecular Weight

506.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1;31 (5) :476-86.|[2]Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20 (4) :500-8.|[3]Junjie Bai, et al. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-Ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Jun 3; S0306-4522 (20) 30353-5.