L-Pipecolic acid

L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases[1][2][3].

Product Specifications

CAS Number

[3105-95-1]

Product Name Alternative

H-HoPro-OH

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/H-HoPro-OH.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1NCCCC1)O

Molecular Formula

C6H11NO2

Molecular Weight

129.16

Precautions

H315, H319, H335

References & Citations

[1]Mihalik SJ, et al. Peroxisomal L-pipecolic acid oxidation is deficient in liver from Zellweger syndrome patients. Pediatr Res. 1989 May;25 (5) :548-52.|[2]Li H, et al. Protective effect of L-pipecolic acid on constipation in C57BL/6 mice based on gut microbiome and serum metabolomic. BMC Microbiol. 2023 May 20;23 (1) :144.|[3]Sato T, et al. Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes. Biosci Biotechnol Biochem. 2016 Nov;80 (11) :2168-2175.