Oryzalin

Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling[1][2][3].

Product Specifications

CAS Number

[19044-88-3]

UNSPSC

12352005

Hazard Statement

H350, H360, H411

Target

Herbicide; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/oryzalin.html

Concentration

10mM

Purity

99.62

Solubility

DMSO : 233.33 mg/mL (ultrasonic)

Smiles

O=S(C1=CC([N+]([O-])=O)=C(N(CCC)CCC)C([N+]([O-])=O)=C1)(N)=O

Molecular Formula

C12H18N4O6S

Molecular Weight

346.36

Precautions

H350, H360, H411

References & Citations

[1]Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172 (2) :252-64.|[2]Bouvier L, et al. Oryzalin as an efficient agent for chromosome doubling of haploid apple shoots in vitro. Plant Breeding, 1994, 113 (4) : 343-346.|[3]Lopes RM, et al. Formulation of oryzalin (ORZ) liposomes: in vitro studies and in vivo fate. Eur J Pharm Biopharm. 2012 Oct;82 (2) :281-90.