Tubercidin

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

Product Specifications

CAS Number

[69-33-0]

Product Name Alternative

7-Deazaadenosine

UNSPSC

12352005

Hazard Statement

H300

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Tubercidin.html

Concentration

10mM

Purity

99.24

Solubility

DMSO : ≥ 30 mg/mL

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO

Molecular Formula

C11H14N4O4

Molecular Weight

266.26

Precautions

H300

References & Citations

[1]Bloch A, et al. On the mode of action of 7-deaza-adenosine (Tubercidin) . Biochim Biophys Acta. 1967 Mar 29;138 (1) :10-25.|[2]Kouni MH, et al. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob Agents Chemother. 1989 Jun;33 (6) :824-7.|[3]Bergstrom DE, et al. Antiviral activity of C-5 substituted tubercidin analogues. J Med Chem. 1984 Mar;27 (3) :285-92.