Broussonin A

Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3].

Product Specifications

CAS Number

[73731-87-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/broussonin-a.html

Purity

Solubility

10 mM in DMSO

Smiles

OC1=CC(OC)=CC=C1CCCC2=CC=C(O)C=C2

Molecular Formula

C16H18O3

Molecular Weight

258.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26 (4) :1194-1205.|[2]Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. |[3]Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14.