Iluzanebart

Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2) . Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) [1].

Product Specifications

CAS Number

[2733621-19-5]

Product Name Alternative

VGL101

UNSPSC

12352203

Target

Ser/Thr Kinase; TREM receptor

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/iluzanebart.html

Purity

98.63

Solubility

10 mM in DMSO

Smiles

[Iluzanebart]

Molecular Weight

(144.92 kDa)

References & Citations

[1]Larson KC, et al., Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. J Neuroinflammation. 2025 Jan 31;22 (1) :26.