(Z/E)-GW406108X
Product Specifications
UNSPSC Description
(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM[1].
Target Antigen
Autophagy; Kinesin; ULK
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-e-gw406108x.html
Smiles
O=C1NC2=CC=C(C(C3=CC=CO3)=O)C=C2/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4
Molecular Weight
400.21
References & Citations
[1]Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477(4):801-814.|[2]Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29(2):148-154.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115570A/Z-E-GW406108X-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115570A/
Clinical Information
No Development Reported
CAS Number
265098-01-9
Curated Selection
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