Isoniazid

Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].

Product Specifications

CAS Number

[54-85-3]

Product Name Alternative

INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Autophagy; Bacterial; Mitophagy

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Isoniazid.html

Purity

99.95

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC=C1)NN

Molecular Formula

C6H7N3O

Molecular Weight

137.14

Precautions

H302

References & Citations

[1]Suarez, J., et al., An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG) . J Biol Chem, 2009. 284 (11) : p. 7017-29.|[2]Timmins, G.S., et al., Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 2004. 48 (8) : p. 3006-9.|[3]Singh, R., et al., PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science, 2008. 322 (5906) : p. 1392-5.|[4]Ahmad, Z., et al., Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig. J Infect Dis, 2009. 200 (7) : p. 1136-43.