USP7-797

USP7-797 (USP7-IN-7) is an orally available, selective USP7 inhibitor (IC50=0.5 nmol/L) with antitumor activity. USP7-797 reduces the level of MDM2, thereby increasing the stability and activity of p53, leading to cell cycle arrest and apoptosis. USP7-797 has low nanomolar cytotoxicity against p53 mutant cancer cell lines, p53 wild-type hematological tumors, and neuroblastoma cell lines[1][2].

Product Specifications

CAS Number

[2413944-70-2]

Product Name Alternative

USP7-IN-7

UNSPSC

12352005

Target

Deubiquitinase; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/usp7-797.html

Concentration

10mM

Purity

99.09

Solubility

DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CC2=CC3=NC=CC(C4=CC(Cl)=CC(C)=C4C[C@@H]5CNCCO5)=C3S2)C6C(C)(C)C6C1=O

Molecular Formula

C27H28ClN3O3S

Molecular Weight

510.05

References & Citations

[1]Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.|[2]Ohol YM, et al. Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo. Mol Cancer Ther. 2020 Oct;19 (10) :1970-1980.