trans-Isoferulic acid-d3
Product Specifications
UNSPSC Description
trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
Target Antigen
NO Synthase; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
OC(/C=C/C(C=C1)=CC(O)=C1OC([2H])([2H])[2H])=O
Molecular Weight
197.20
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of <i>Clematis florida var. plena</i>. Nat Prod Res. 2019 Oct;33(20):2925-2931.|[3]Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan18(1):203-11.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1028203-97-5
Curated Selection
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