LH1513
Product Specifications
UNSPSC Description
LH1513 is a dioxalate derivative of l-lysine (HY-N0469) that inhibits CaOx crystallization with better activity than citrate and pyruvate. LH1513 has potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolism[1].
Target Antigen
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/lh1513.html
Smiles
O=C(C(NCCCC[C@H](NC(C(O[Na])=O)=O)C(O[Na])=O)=O)O[Na]
Molecular Weight
356.17
References & Citations
[1]Hu L, et al. Discovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria. ACS Med Chem Lett. 2024 Nov 4;15(11):2005-2011.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159910/LH1513-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159910/
Clinical Information
No Development Reported
Curated Selection
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