LH1513

LH1513 is a dioxalate derivative of l-lysine (HY-N0469) that inhibits CaOx crystallization with better activity than citrate and pyruvate. LH1513 has potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolism[1].

Product Specifications

UNSPSC

12352211

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lh1513.html

Smiles

O=C(C(NCCCC[C@H](NC(C(O[Na])=O)=O)C(O[Na])=O)=O)O[Na]

Molecular Formula

C10H11N2Na3O8

Molecular Weight

356.17

References & Citations

[1]Hu L, et al. Discovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria. ACS Med Chem Lett. 2024 Nov 4;15 (11) :2005-2011.