LH1513
LH1513 is a dioxalate derivative of l-lysine (HY-N0469) that inhibits CaOx crystallization with better activity than citrate and pyruvate. LH1513 has potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolism[1].
Product Specifications
UNSPSC
12352211
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lh1513.html
Smiles
O=C(C(NCCCC[C@H](NC(C(O[Na])=O)=O)C(O[Na])=O)=O)O[Na]
Molecular Formula
C10H11N2Na3O8
Molecular Weight
356.17
References & Citations
[1]Hu L, et al. Discovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria. ACS Med Chem Lett. 2024 Nov 4;15 (11) :2005-2011.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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