Tephrosin

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1].

Product Specifications

CAS Number

[76-80-2]

Product Name Alternative

Deguelinol I; Hydroxydeguelin

UNSPSC

12352005

Hazard Statement

H410

Target

EGFR

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tephrosin.html

Purity

98.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@]2(O)[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14

Molecular Formula

C23H22O7

Molecular Weight

410.42

Precautions

H410

References & Citations

[1]Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293 (1) :23-30.