1,4-PBIT (dihydrobromide)

1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively[1].

Product Specifications

CAS Number

[157254-60-9]

Product Name Alternative

1,4-PB-ITU (dihydrobromide)

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-4-pbit-dihydrobromide.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

NC(SCCC1=CC=C(CCSC(N)=N)C=C1)=N.[H]Br.[H]Br

Molecular Formula

C12H20Br2N4S2

Molecular Weight

444.25

References & Citations

[1]E P Garvey, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269 (43) :26669-76.