NGX-267
NGX-267 is a selective agonist of the actin M1 receptor, which has high selectivity among the five actin receptor subtypes, especially for the M1 receptor rather than the M3 receptor. NGX-267 also has significant differences in affinity for dopamine D2 and 5-HT2B receptors[1].
Product Specifications
CAS Number
[503431-81-0]
Product Name Alternative
AF-267B
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ngx-267.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@@H]1SC2(CCN(CC2)C)NC1=O
Molecular Formula
C10H18N2OS
Molecular Weight
214.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor
Available Sizes
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