Sp-5,6-DCl-cBIMPS (sodium)
Product Specifications
UNSPSC Description
Sp-5,6-DCl-cBIMPS sodium is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].
Target Antigen
PKA
Type
Reference compound
Related Pathways
Stem Cell/Wnt;TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sp-5-6-dcl-cbimps-sodium.html
Smiles
O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@]2(S[Na])=O)([H])N(C=NC3=C4)C3=CC(Cl)=C4Cl
Molecular Weight
419.15
References & Citations
[1]Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7.|[2]Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22.|[3]Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137638A/Sp-5-6-DCl-cBIMPS-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137638A/
Clinical Information
No Development Reported
CAS Number
142439-96-1
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