4-Hydroxyestradiol

4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141) . 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].

Product Specifications

CAS Number

[5976-61-4]

Product Name Alternative

4-Hydroxy-17β-estradiol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-hydroxyestradiol.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@](CC[C@@H]2O)([H])[C@@](CCC3=C4O)([H])[C@@](CC1)([H])C3=CC=C4O

Molecular Formula

C18H24O3

Molecular Weight

288.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Fernandez SV, et al. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer. 2006 Apr 15;118 (8) :1862-8. doi: 10.1002/ijc.21590.|[2]Van Aswegen CH, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32 (4) :485-92.