Schisandrin B

Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

Product Specifications

CAS Number

[61281-37-6]

Product Name Alternative

γ-Schisandrin; Wuweizisu B

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Schisandrin-B.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1)C(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC

Molecular Formula

C23H28O6

Molecular Weight

400.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Checker R, et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free Radic Biol Med. 2012 Oct 1;53 (7) :1421-30.|[2]Lam PY, et al. Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. Oxid Med Cell Longev. 2012;2012:250825.|[3]Zeng KW, et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Oct 5;692 (1-3) :29-37.|[4]Liu Z, et al. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS One. 2012;7 (7) :e40480.|[5]Zhu S, et al. Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med. 2012;40 (3) :551-66.