Tectol

Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM[1]. Tectol is a farnesyltransferase (FTase) inhibitor with IC50s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC50 of 3.44 μM[1][2].

Product Specifications

CAS Number

[24449-39-6]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Farnesyl Transferase; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tectol.html

Purity

99.72

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC1=C(C=CC=C2)C2=C(O3)C(C=CC3(C)C)=C1C4=C(C=CC5(C)C)C(O5)=C6C(C=CC=C6)=C4O

Molecular Formula

C30H26O4

Molecular Weight

450.53

Precautions

H315, H319

References & Citations

[1]Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64 (6) :792-795.|[2]Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24 (14) :3102-3107.