BCL-XL-IN-3
Product Specifications
UNSPSC Description
BCL-XL-IN-3 (Compound 11) is an inhibitor for BCL-XL with a Ki EC50 of 77.8 nM and 0.07 nM. BCL-XL-IN-3 can be used as ADC toxin for synthesis of Clezutoclax (HY-137774)[1].
Target Antigen
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-xl-in-3.html
Smiles
O[C@H](CO)CCNCCO[C@](C1)(C2)C[C@@](C[C@@]2(C3)C)(C[C@]13C)CN4C(C)=C(C(C=CC(N(CCC5=CC=C6)CC5=C6C(NC7=NC8=CC=CC=C8S7)=O)=N9)=C9C(O)=O)C=N4
Molecular Weight
834.04
References & Citations
[1]Judd AS, et al., BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors. Sci Adv. 2024 Oct 4;10(40):eado7120.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-170406/BCL-XL-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170406/
Clinical Information
No Development Reported
CAS Number
1949840-87-2
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