Prednisolone

Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research[1][2].

Product Specifications

CAS Number

[50-24-8]

UNSPSC

12352211

Hazard Statement

H302, H312, H315, H319, H332

Target

Endogenous Metabolite; Glucocorticoid Receptor

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Prednisolone.html

Purity

99.93

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : 0.1 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C1

Molecular Formula

C21H28O5

Molecular Weight

360.44

Precautions

H302, H312, H315, H319, H332

References & Citations

[1]Prednisolone. J Am Pharm Assoc. 1976;16 (3) :143-146.|[2]Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565 (1-2) :89-102.|[3]Hahn B H, et al. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in nzp/nzw mice. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 1973, 16 (2) : 163-170.|[4]NOWELL PC. Inhibition of human leukocyte mitosis by prednisolone in vitro. Cancer Res. 1961 Dec;21:1518-21.