SAH-EZH2
Product Specifications
UNSPSC Description
SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27[1].
Target Antigen
Histone Methyltransferase
Type
Peptides
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sah-ezh2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@]1(NC([C@@H](NC([C@](NC([C@@H](NC([C@](C)(CCC/C=C/CCC1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CO)NC([C@@H](NC(C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)CCCCN)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)C)N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Weight
3431.99
References & Citations
[1]Woojin Kim, et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct;9(10):643-50.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2266/SAH-EZH2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2266/
Clinical Information
No Development Reported
CAS Number
1453222-26-8
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