Nortriptyline

Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects[1][2][3]. N

Product Specifications

CAS Number

[72-69-5]

Product Name Alternative

Desmethylamitriptyline; Desitriptilina

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Drug Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nortriptyline.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13

Molecular Formula

C19H21N

Molecular Weight

263.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD) : National Center for Biotechnology Information (US) ; March 23, 2017.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.