Ceftolozane

Ceftolozane (CXA-101 free base; FR264205 free base) is a cephalosporin antibiotic with potent activity againstPseudomonas aeruginosa and strains Enterobacteriaceae, with MICs of 0.5 and 0.25-0.5 mg/L[1].

Product Specifications

CAS Number

[689293-68-3]

Product Name Alternative

CXA-101 (free base) ; FR264205 (free base)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ceftolozane.html

Purity

98.78

Solubility

DMSO : 24 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N

Molecular Formula

C23H30N12O8S2

Molecular Weight

666.69

Precautions

H302, H312, H332

References & Citations

[1]Craig WA, et al., In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother. 2013 Apr;57 (4) :1577-82.