Segetalin B

Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) [1][2][3][4].

Product Specifications

CAS Number

[164991-89-3]

UNSPSC

12352209

Target

Estrogen Receptor/ERR; RUNX; Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/segetalin-b.html

Purity

99.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N1)=O)C)=O)C(C)C)=O)=O)C)[C@@H]1CC2=CNC3=CC=CC=C23

Molecular Formula

C24H32N6O5

Molecular Weight

484.55

References & Citations

[1]HiroshiMorita, et al. Segetalins B, C and D, three new cyclic peptides from Vaccaria segetalis. Tetrahedron Volume 51, Issue 21, 22 May 1995, Pages 6003-6014.|[2]PascalSonnet, et al. First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity. Tetrahedron Letters. Volume 44, Issue 16, 14 April 2003, Pages 3293-3296|[3]DONG H, et al. HPLC simultaneous determination of segetalin A and segetalin B in Vaccariae Semen[J]. Chinese Journal of Pharmaceutical Analysis, 2012, 32 (5) : 793-796.|[4]Lan X, et al. SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation. Drug Dev Res. 2022 Dec;83 (8) :1845-1857.