Fenhexamid

Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) [1].

Product Specifications

CAS Number

[126833-17-8]

Product Name Alternative

KBR 2738

UNSPSC

12352005

Hazard Statement

H411

Target

Estrogen Receptor/ERR; Fungal; PI3K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/fenhexamid.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C(Cl)=C1Cl)O)C2(CCCCC2)C

Molecular Formula

C14H17Cl2NO2

Molecular Weight

302.20

Precautions

H411

References & Citations

[1]Debieu D, et al. The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea) . Pest Manag Sci. 2001 Nov;57 (11) :1060-7.|[2]Go RE, et al., Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models. Toxicol Appl Pharmacol. 2015 Nov 15;289 (1) :48-57.|[3]Medjakovic S, et al., Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor. Environ Toxicol. 2014 Oct;29 (10) :1201-16.|[4]Go RE, et al., A fungicide, fenhexamid, is involved in the migration and angiogenesis in breast cancer cells expressing estrogen receptors. Life Sci. 2022 Sep 15;305:120754.