Pyrimidine
Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research[1][2][3].
Product Specifications
CAS Number
[289-95-2]
UNSPSC
12352005
Hazard Statement
H226
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pyrimidine.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1=NC=CC=N1
Molecular Formula
C4H4N2
Molecular Weight
80.09
Precautions
H226
References & Citations
[1]Halbrook CJ, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metab. 2019 Jun 4;29 (6) :1390-1399.e6.|[2]Inoue K. Microglial activation by purines and pyrimidines. Glia. 2002 Nov;40 (2) :156-163.|[3]Taglieri L, et al. Discovery of a pyrimidine compound endowed with antitumor activity. Invest New Drugs. 2020 Feb;38 (1) :39-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Available Sizes
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