DSP-1053
DSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity[1].
Product Specifications
CAS Number
[1176326-76-3]
UNSPSC
12352005
Target
5-HT Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DSP-1053.html
Purity
99.75
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(CC2CCN(CCC3=CC(C(CCO4)=O)=C4C=C3)CC2)C=C1OCCOC
Molecular Formula
C26H32BrNO4
Molecular Weight
502.44
References & Citations
[1]Yoshinaga H, et al. Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity. Bioorg Med Chem. 2018 May 1;26 (8) :1614-1627.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
Curated Selection
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