Toladryl
Product Specifications
UNSPSC Description
Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303). The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].
Target Antigen
Endogenous Metabolite; Histamine Receptor; iGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/toladryl.html
Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C)C=C2
Molecular Weight
269.38
References & Citations
[1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β-(P-methylbenzhydryloxy)-ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21(4): 353-370.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138110/Toladryl-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138110/
Clinical Information
No Development Reported
CAS Number
19804-27-4
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