Toladryl

Toladryl is a derivative of Diphenhydramine (HY-B0303), capable of penetrating the blood-brain barrier and possessing oral activity, as well as antihistamine and anticholinergic activities. The anticholinergic activity of Toladryl is approximately one-tenth that of Diphenhydramine (HY-B0303), and its protective effect against lethal doses of histamine in guinea pigs is 2 to 4 times that of Diphenhydramine (HY-B0303) . The side effects of Toladryl are fewer and milder than those of Diphenhydramine (HY-B0303), but at higher doses, it may cause central nervous system symptoms such as insomnia, agitation, and disorientation. Toladryl can be used for research in allergic diseases[1].

Product Specifications

CAS Number

[19804-27-4]

Product Name Alternative

4-Methyldiphenhydramine

UNSPSC

12352005

Hazard Statement

H302

Target

Endogenous Metabolite; Histamine Receptor; iGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/toladryl.html

Purity

97.23

Smiles

CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(C)C=C2

Molecular Formula

C18H23NO

Molecular Weight

269.38

Precautions

H302

References & Citations

[1]McGavack T H, et al. Newer antihistaminics: III. Some pharmacologic and therapeutic effects of β- (P-methylbenzhydryloxy) -ethyldimethylamine hydrochloride, a derivative of diphenhydramine hydrochloride[J]. Journal of Allergy, 1950, 21 (4) : 353-370.