1,2-DLPC

1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells[1][2][3].

Product Specifications

CAS Number

[18194-25-7]

Product Name Alternative

1,2-Dilauroyl-sn-glycero-3-phosphocholine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H331, H336, H351, H361, H372, H412

Target

Apoptosis; Liposome; PPAR; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-2-dilauroyl-sn-glycero-3-phosphocholine.html

Purity

98.0

Solubility

Ethanol : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C32H64NO8P

Molecular Weight

621.83

Precautions

H302, H315, H319, H331, H336, H351, H361, H372, H412

References & Citations

[1]Matthew E Nipper, et al. Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors. Biochimie. 2011 Jun;93 (6) :988-94.|[2]Jae Man Lee, et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 2011 May 25;474 (7352) :506-10.|[3]Jinwoo Park, et al. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine increases insulin sensitivity in palmitate-treated myotubes and induces lipolysis in adipocytes. Biochem Biophys Res Commun. 2020 Nov 26;533 (1) :162-167.