ZK164015
Product Specifications
UNSPSC Description
ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
Target Antigen
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/zk164015.html
Smiles
OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1
Molecular Weight
513.73
References & Citations
[1]Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103455/ZK164015-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103455/
Clinical Information
No Development Reported
CAS Number
177583-70-9
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