fluoro-Dapagliflozin
Product Specifications
UNSPSC Description
fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with Ki values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents[1].
Target Antigen
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fluoro-dapagliflozin.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)OCC)=C(C=C2)Cl)O[C@@H]([C@H]([C@@H]1O)F)CO
Molecular Weight
410.86
References & Citations
[1]Charles S Hummel, et al. Structural selectivity of human SGLT inhibitors. Am J Physiol Cell Physiol. 2012 Jan 15;302(2):C373-82.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122473/fluoro-Dapagliflozin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122473/
Clinical Information
No Development Reported
CAS Number
1181681-43-5
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