JBC117
Product Specifications
UNSPSC Description
JBC117 is a novel anticancer lead compound targeting Pygo2 PHD. JBC117 can effectively antagonize the cell effect of β-catenin-dependent activity and inhibit the migration and invasion of cancer cells. JBC117 can induce apoptosis[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jbc117.html
Solubility
10 mM in DMSO
Smiles
OC(CN1CCC2(CC1)OC3=C(C(C2)O)C=CC4=C3C=CC=C4)C5=CNC6=C5C=CC(C)=C6
Molecular Weight
442.55
References & Citations
[1]Ali F, et al. Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2. Cancer Sci. 2016 Sep;107(9):1321-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157891/JBC117-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157891/
Clinical Information
No Development Reported
CAS Number
1214531-21-1
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