Elacestrant-d4-1

Elacestrant-d4-1 is the deuterium labeled Elacestrant (HY-19822) . Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively[1][2].

Product Specifications

Product Name Alternative

RAD1901-d4-1

UNSPSC

12352005

Target

Estrogen Receptor/ERR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

OC1=C([2H])C=C2C[C@H](C3=CC([2H])=C(OC)C([2H])=C3N(CC)CC4=CC=C(CCNCC)C=C4)CCC2=C1[2H]

Molecular Formula

C30H34D4N2O2

Molecular Weight

462.66

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26 (9) :948-56.