TRP1 / Tyrosinase-Related Protein-1 Antibody
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
UniProt
P17643
Host
Rabbit
Immunogen
Recombinant human TYRP1 protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tyrosinase-Related Protein-1 antibody is available for research use only.
CAS Number
9007-83-4
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