Ribonucleotide Reductase M1 Recombinant Antibody / RRM1
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Product Specifications
UniProt
P23921
Host
Rabbit
Immunogen
A portion of amino acids 700-800 of human RRM1 was used as the immunogen for the RRM1 antibody.
Clonality
Monoclonal
Isotype
IgG
Type
Recombinant
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the RRM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This RRM1 antibody is available for research use only.
CAS Number
9000-83-3
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