A2M Antibody / Alpha-2-Macroglobulin
Alpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P01023
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
A2M/3623
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the A2M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This A2M antibody is available for research use only.
Storage Conditions
Store the A2M antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the A2M antibody should be determined by the researcher.
Location
Secreted
Image Legend
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