TRP1 / Tyrosinase-Related Protein-1 Antibody
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
UniProt
P17643
Host
Mouse
Immunogen
A recombinant human partial protein (amino acids 257-377) was used as the immunogen for this Tyrosinase-Related Protein-1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
ELISA, IHC-P
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Tyrosinase-Related Protein-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Tyrosinase-Related Protein-1 antibody is available for research use only.
CAS Number
9007-83-4
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