PAPP-A Antibody / Pappalysin-1
The PAPPA gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [RefSeq]
Product Specifications
UniProt
Q13219
Host
Mouse
Immunogen
A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PAPPA antibody is available for research use only.
CAS Number
9007-83-4
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