Ku70 + Ku80 Antibody
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D) J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
LKAP1-1
Applications
FACS, IF
Purity
Protein G purified
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Ku70 + Ku80 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Ku70 + Ku80 antibody is available for research use only.
Storage Conditions
Store the Ku70 + Ku80 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Titering of the Ku70 + Ku80 antibody may be required for optimal performance.
Location
Nuclear
Image Legend
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