PMEL17 / Melanoma gp100 Antibody
PMEL17/Melanoma gp100/SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. [UniProt]<p>The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60-64 kDa), which is subsequently cleaved to generate 26kDa and 34-38kDa fragments.
Product Specifications
UniProt
P40967
Host
Mouse
Immunogen
Recombinant human protein was used as the immunogen for the PMEL17 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
IHC-P, WB
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PMEL17 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PMEL17 antibody is available for research use only.
CAS Number
9007-83-4
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