Bcl-2 Antibody
Bcl2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. [UniProt]
Product Specifications
UniProt
P10415
Host
Mouse
Immunogen
Recombinant full-length human protein was used as the immunogen for the Bcl2 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
IHC-P
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Bcl2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Bcl2 antibody is available for research use only.
CAS Number
9007-83-4
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
