14-3-3 sigma Antibody / SFN
SFN (Stratifin), also called 14-3-3 Sigma, is a p53-induced tumor suppressor gene which is activated in response to DNA damage, causing cell cycle arrest at G2 phase by blocking cdc2-cyclin B1 complex from entering the nucleus. It is inactivated in breast, lung, prostate, liver and gastric cancer. It is associated with poor prognosis when its down-regulation is observed in epithelial ovarian cancer. SFN expression could contribute to cancer cell proliferation and the development and/or progression of human gastrointestinal cancer.
Product Specifications
UniProt
P31947
Host
Mouse
Immunogen
Full length recombinant human protein was used as the immunogen for the 14-3-3 Sigma antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
WB, IHC-P
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the 14-3-3 Sigma antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This 14-3-3 Sigma antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6699141/datasheet/v3999saf-100ug.pdf
CAS Number
9007-83-4
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