DOG1 Recombinant Antibody / TMEM16A / ANO1
Expression of DOG1/ANO1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for ANO1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of ANO1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
Product Specifications
UniProt
Q5XXA6
Host
Mouse
Immunogen
A recombinant human full length protein was used as the immunogen for this recombinant ANO1 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Type
Recombinant
Applications
IHC-P
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant ANO1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant ANO1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6697781/datasheet/v3567ihc-7ml.pdf
CAS Number
9000-83-3
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