CD11b Antibody / MAC-1
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Product Specifications
Host
Mouse
Immunogen
Recombinant human CD11b/ITGAM protein was used as the immunogen for this antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
FACS, IF
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11b antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6697650/datasheet/v3528-20ug.pdf
CAS Number
9007-83-4
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