Thymidylate Synthase Antibody
This antibody recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS, TYMS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Product Specifications
UniProt
P04818
Host
Mouse
Immunogen
A recombinant human parital protein corresponding to amino acids 60-174 was used as the immunogen for this TYMS antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Applications
IHC-P
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the TYMS antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TYMS antibody is available for research use only.
CAS Number
9007-83-4
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