Gp96 Antibody / GRP94 / HSP90B1
Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96) . Gp96 shows a high degree of sequence homology with the heat shock protein 90 (hsp90) . This mAb is highly specific and shows minimal cross-reaction with other members of the HSP90 family. Grps are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Gp96 has been briefly studied as a prognostic factor in breast cancer.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P14625
Host
Rat
Reactivity
Human
Immunogen
Purified glucose regulated protein 94 from chicken oviducts was used as the immunogen for the gp96 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
SPM249
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the gp96 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This gp96 antibody is available for research use only.
Storage Conditions
Store the gp96 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic and nuclear
Image Legend
IHC analysis of formalin-fixed, paraffin-embedded human breast carcinoma stained with gp96 antibody (SPM249) .
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